Mollarets meningitis article pdf available in the lancet infectious diseases 1410. Mollaret meningitis definition of mollaret meningitis by. Mollaret meningitis is characterized by recurrent episodes of aseptic meningitis lasting 3 to 5 days followed by spontaneous recovery. The features of these activated monocytes were compatible with those of mollaret s cells, and csf herpes simplex virus type 2 hsv2 pcr assay was positive. Mollarets meningitis fulltext european neurology 2008, vol. The present case may be the first case of hsv type 2 mollarets meningitis to be documented in. Mollaret meningitis, recurrent aseptic meningitis, fever. Early diagnosis may prevent prolonged hospital admissions. But we usually dont do an hsv pcr on all presumedly viral meningitides. Mollaret s meningitis is caused by herpes simplex virus. Mollaret meningitis is a rare form of recurrent aseptic meningitis, usually due to hsv2 infection, which can be detected by hsv pcr. It is not known why one person gets meningitis when others exposed to the same germs do not get as sick, or dont get sick at all.
Hydrocele and hernia ucsf department of urology ucsf. Mollaret meningitis was first described by mollaret in 1944 as a form of aseptic meningitis. By continuing to use our website, you are agreeing to our use of cookies. We report a case of mollaret meningitis in a sevenyearold girl who presented with four aseptic meningitis episodes in one year. Mollaret was the first to describe a rare form of meningitis that presented as recurrent and brief selflimiting attacks of fever, headache, vomiting, and meningeal irritation with no obvious etiology. Pdf on oct 1, 2014, zaw min and others published mollarets meningitis find, read and cite all the research you need on researchgate. In recent years there has been increasing evidence to implicate the herpes simplex virus 2 hsv2 in many cases. Since mollaret s meningitis is a recurrent, benign noncancerous, aseptic meningitis, it is also referred to as benign recurrent lymphocytic meningitis. Sometimes funguses, cancers, head injuries or other factors can cause meningitis, but cases from these sources are rare. Symptoms of mollaret meningitis, which last from 1 to 7 days, include headache, neck ache, fever, and neck stiffness. Recurrent herpes simplex virus type 2 meningitis semantic scholar.
Causes of meningitis meningitis is due to infection with either viruses or bacteria. A 72yearold woman, previously in good health, suffered for 2 years from attacks of a complex neuropsychiatric syndrome lasting from 2 days to 4 weeks. Meningitis awareness week is held between 17th23rd september 2018 in the uk. Idiopathic hypertrophic pachymeningitis genetic and rare. This syndrome is associated with tra we use cookies to enhance your experience on our website. Perimeningitis definition at, a free online dictionary with pronunciation, synonyms and translation. Mollarets meningitis is a rare form of idiopathic recurrent aseptic meningitis that has a sudden onset, short duration, and spontaneous remission. Twentyeight years of benign recurring mollaret meningitis jama. These episodes, which were followed by intervals of nearly complete recovery, were usually marked by fever, headache, mental confusion, vomiting, ataxia, anisocoria, epileptic seizures and stiffness of the neck. Pdf herpes simplex virus type 2associated recurrent aseptic.
Herpes simplex virus type 2associated recurrent aseptic. Mollaret meningitis is characterized by three or more episodes of benign recurrent aseptic meningitis in which symptoms and signs resolve spontaneously. Should mollarets meningitis always be treated with antihsv. Mollaret meningitis genetic and rare diseases information. In general, meningitis due to bacteria bacterial meningitis is more severe than meningitis caused by viruses viral meningitis. A case of benign recurrent meningitis of mollaret springerlink. In general, meningitis caused by a virus is less serious than meningitis caused by bacteria. Nov, 2012 mollaret meningitis is a rare form of recurrent aseptic meningitis, usually due to hsv2 infection, which can be detected by hsv pcr. These cells are thought by many to be the hallmark of mollaret s meningitis and early on may comprise 60% to 70% of the csf cells. Mollaret meningitis the turkish journal of pediatrics. Joseph was born on june 23 1865, in saintpierredechartreuse, france. Herpes simplex type 2 virus is the causative agent in virtually all cases.
The episodes of meningitis usually last from two to five days and then go away on their own, but the time in between episodes varies among people with the disease, from weeks to years. They bring forward evidence for the blastomatous nature of partly cornified epithelial cells present in their case. Mollarets meningitis benign recurrent aseptic meningitis. It has been suggested that if the strict criteria above are followed, these cases should be excluded, and the term mollaret s meningitis reserved for true idiopathic cases. Nov 01, 2006 recurrent benign lymphocytic meningitis is a recurring, typically innocuous, painful form of aseptic meningitis. Recurrent benign lymphocytic meningitis clinical infectious. Mollaret s meningitis is a recurrent inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. If you have experienced viral meningitis more than once, we would encourage you to ask your gp to investigate it to try and determine the cause. Pdf mollarets meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. Mollarets meningitis is a rare form of benign, recurrent aseptic meningitis characterized by the appearance of a particular mononuclear cell in the csf during the first few days of the illness. Bamberger, md, university of missourikansas city school of medicine, kansas city, missouri a cute meningitis is a medical emer. If you have problems viewing pdf files, download the latest version of adobe reader for language access assistance, contact the ncats public information officer genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree.
Asceptic recurrent viral meningitis mollarets meningitis. Herpes simplex virus type 2associated recurrent aseptic mollarets. For adults with certain medical conditions to prevent meningitis, pneumonia and other serious infections. Mollarets meningitisrecurrent aseptic meningitishsv2 virus. This is a rare condition believed to be caused in many cases by infection with a member of the herpes family of viruses. You get it when a virus enters the body through the nose or mouth and travels to the brain. Mar 30, 2017 idiopathic hypertrophic pachymeningitis ihp is a rare disorder causing inflammation and thickening of the outer layer dura of the brain andor spinal cord. Secondary meningitis is that which develops following direct entry of bacteria into the central nervous system, which can occur at the time of neurosurgery, in association with trauma, or through an abnormal communication between the external environment and the. Recurrent meningitis albert einstein college of medicine. Emile cyprien mollaret was born on month day 1904, at birth place, to joseph emile mollaret and josephine francoise mollaret born gonthier. Mollaret s cells can be demonstrated by the papanicolaou stain and are now thought to be large activated cells of the monocyte macrophage lineage. Get a printable copy pdf file of the complete article 869k, or click on a page.
Mollarets meningitis is a rare condition with a characteristic clinical and cerebrospinal fluid picture. Mollarets meningitis recurrent aseptic meningitishsv2 virus. Diagnosis, initial management, and prevention of meningitis david m. Hydrocele and hernia male and female hydrocele a hydrocele is a painless collection of fluid surrounding the testicle which makes the scrotum appear large see figure 1. In many ways it resembles recurrent hereditary polyserositis familial mediterranean fever in its natural history, pattern of attacks, and response to colchicine. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. An epidermoid cyst of the 3rd ventricle was verified by necropsy in a man of 60 with three episodes of mollarets aseptic leukocyticendothelial meningitis. It is coordinated by meningitis research foundation and aims to improve public understanding of meningitis and septicaemia. Mollaret meningitis mollahra, a recurrent aseptic meningitis. Recurrent meningitis is a rare clinical scenario that can be selflimiting or life threatening depending on the underlying etiology.
Most children with viral meningitis recover completely. Mollarets meningitis is the name given to a recurring form of meningitis. Diagnosis, initial management, and prevention of meningitis. This may not be the complete list of references from this article. Benign recurrent aseptic meningitis mollarets meningitis. Mollaret s meningitis and differential diagnosis of recurrent meningitis. Here are links to possibly useful sources of information about mollaret s meningitis. Contribution to the background of mollarets meningitis.
Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. Much rarer causes include fungi or malignant cancer cells. What links here related changes upload file special pages permanent. Emile mollaret historical records and family trees myheritage. Capitulo 10 infecciones del sistema nervioso 10 central. Hsv2 diagnostico mediante pcr sesiones generales caule. The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Jan 25, 2019 mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. Mollaret s meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Am representing the vast majority of meningitis in our society. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
With this type of meningitis, there is usually rapid onset of symptoms and resolution. Mollarets meningitis is defined as a benign recurrent aseptic meningitis. Mollarets meningitis should be suspected in all cases of recurrent lymphocytic meningitis. Mollaret syndrome definition of mollaret syndrome by. Mollarets meningitis is a recurrent or chronic inflammation of the protective membranes. Mollarets meningitis an overview sciencedirect topics. Mollarets meningitis and herpes simplex virus type 1 nejm. Large degenerated monocytes were present as ghost cells asterisks. Mollaret meningitis is characterized by recurrent episodes of viral meningitis. Mollaret s meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and various neurological deficits that last for a few days in a selflimiting fashion.